Non-communicable diseases (NCDs) have emerged as a leading cause of morbidity and mortality worldwide, particularly in low- and middle-income countries. Cardiovascular diseases, diabetes, cancers, and chronic respiratory illnesses account for the majority of these deaths. The growing burden of NCDs has highlighted the critical role of public health systems in prevention, early detection, and management. This article explores the challenges faced by public health infrastructures in tackling NCDs and outlines evidence-based strategies to enhance their capacity and effectiveness. A strong public health framework is essential to achieving sustainable health outcomes and addressing the social determinants that influence NCD prevalence.