Spontaneous splenic rupture is an uncommon but potentially life-threatening complication of infectious mononucleosis (IM). Early diagnosis is critical due to the risk of hemorrhagic shock. We present the case of a 24-year-old male who developed acute abdominal pain and hemodynamic instability secondary to splenic rupture without prior trauma. Prompt surgical intervention led to a favorable outcome. This report highlights the importance of clinical suspicion, imaging studies, and timely management.