Plasmablastic Lymphoma: A Retrospective Study from a Single Tertiary Center in Brazil

Maura Helena Folharini Barbosa

Department of Hematology and Oncology

*Corresponding Author Maura Helena Folharini Barbosa, Department of Hematology and Oncology, Irmandade Da Santa Casa De Misericórdia De São Paulo, Email id: maurafolharini@gmail.com

Abstract

Background: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma, strongly associated with HIV infection and immunosuppression. Despite advances in therapy, outcomes remain poor and there is no established standard of care. Objectives: To evaluate the clinical, epidemiological, histopathological characteristics and treatment outcomes of patients diagnosed with PBL at a tertiary referral center in Brazil. Methods: We conducted a retrospective longitudinal study including all patients diagnosed with PBL at the Hematology and Hemotherapy Department of Santa Casa de São Paulo. Clinical data, laboratory parameters, histopathological findings, treatment regimens, and outcomes were reviewed from medical records. Conclusion: PBL remains a highly aggressive lymphoma with heterogeneous presentation and poor outcomes. Larger multicenter studies are needed to define optimal therapeutic strategies.